PI Health Sciences

Overview

PI Health Sciences is a leading Contract Research, Development and Manufacturing Organization (CRDMO) providing integrated solutions from discovery through development and manufacturing for big pharma and biotech partners. A subsidiary of PI Industries (founded 1946), the organization combines 80 years of scientific expertise with modern capabilities across small molecules and biologics.

Discovery Services

• Integrated Drug Discovery (IDD): Co-located teams combining synthetic and medicinal chemistry, biology, and AI technologies
• AI & Computational Chemistry: Advanced molecular modeling and in silico approaches
• Discovery Chemistry: Scaffold synthesis, impurity characterization, strategic IP evaluation
• Discovery Biology: Target validation, biochemical and cellular screening, ADME, pharmacokinetics profiling, in vivo efficacy
• DMPK Services: Drug metabolism and pharmacokinetics profiling
• Preclinical Services: Comprehensive preclinical support

Development & CMC Solutions

• Process Development: Route scouting, process chemistry, process development, and optimization
• Process Safety: Advanced safety evaluations, hazard identification and assessment, thermal stability analysis, dust explosion testing
• Analytical Services: Method development and validation, genotoxic impurity analysis, stability and forced degradation testing, potent compound analysis, trace metal testing
• Non-GMP Scale-Up: Phase-appropriate development with GMP/non-GMP scale-up capabilities
• Salt and Polymorph Screening: Solid-state characterization services

Manufacturing Services

• Preclinical, clinical, and commercial manufacturing
• High potency capabilities
• Advanced chemistry expertise
• Regulatory compliance focus

Enabling Technologies

• Flow Chemistry: Integrated flow chemistry services
• Biocatalysis: Integrated biocatalysis services
• In Silico Genotoxicity: Computational genotoxicity assessment

Project Management

Certified project managers employing agile methodologies, advanced data analytics, and cloud-based collaboration tools with regulatory compliance focus.